Evolutionary aspects of thymology in pediatric practice

The thymus is now considered a derivative of the immune system being, to greater extent, its central organ. Immunodeficiency states and dysregulation also depend on quality thymus, which may be determined both genetically by fetopathic approach as well due possibility mode intravital injuries, age-related involution over different periods life. Not accidentally, there are various morphometric bipolar gland in pediatric population (3-7%), whereas size sufficiently larger or smaller than reference variable values. In certain cases, phenomenon thymomegaly (for example, newborns) result genetic errors (neuro-endocrine-immune syndrome with thymomegaly) induced mutated Hox genes. This associated congenital heart disorders. Moreover, excessive morbidity respiratory infections (commonly, viral their etiology) among young children conditions remains subject sharp discussions. Some works assessing status subjected forced thymectomy, e.g., during surgery, yielded quite controversial results, even cases subtotal removal gland. Dialectically, concepts “morphology” “organ function” could not separated from one another. transformations organs (even transient ones) occuring within range > 95 < 5 percentiles, should almost always underlied pathomorphosis require verification causes origin. Even today, however, assessment pathomorphology deceased critical, being often descriptive. situation is, probably, extreme complexity thymic morphology assessment. final point seems set discussion about immunodeficiency transformations. current absence reliable immune-mediated biomarkers, limited availability diagnostics primary conditions, decreased interest clinical science issues at early age, longitudinal observations this category patients, etc. article, authors attempt draw attention researchers problem.